preparation of plga nanofiber scaffold in tissue engineering using electrospinning technique

PLGA nanofiber-coated silk microfibrous scaffold for connective tissue engineering.

A modified degumming technique, involving boiling in 0.25% Na2CO3 with addition of 1% sodium dodecyl sulphate and intermittent ultrasonic agitation, was developed for knitted silk scaffolds. Sericin was efficiently removed, while mechanical and structural properties of native silk fibroin were preserved. Biocompatible and mechanically robust hybrid nano-microscaffolds were fabricated by coating...

Morphological Effects of HA on the Cell Compatibility of Electrospun HA/PLGA Composite Nanofiber Scaffolds

Tissue engineering is faced with an uphill challenge to design a platform with appropriate topography and suitable surface chemistry, which could encourage desired cellular activities and guide bone tissue regeneration. To develop such scaffolds, composite nanofiber scaffolds of nHA and sHA with PLGA were fabricated using electrospinning technique. nHA was synthesized using precipitation method...

PLGA/nHA hybrid nanofiber scaffold as a nanocargo carrier of insulin for accelerating bone tissue regeneration

The development of tissue engineering in the field of orthopedic surgery is booming. Two fields of research in particular have emerged: approaches for tailoring the surface properties of implantable materials with osteoinductive factors as well as evaluation of the response of osteogenic cells to these fabricated implanted materials (hybrid material). In the present study, we chemically grafted...

Fabrication of Chitosan Based Nanofibrous Scaffold Using Free Surface Electrospinning for Tissue Engineering Application

Myocardial tissue engineering using electrospun nanofiber composites

Emerging trends for cardiac tissue engineering are focused on increasing the biocompatibility and tissue regeneration ability of artificial heart tissue by incorporating various cell sources and bioactive molecules. Although primary cardiomyocytes can be successfully implanted, clinical applications are restricted due to their low survival rates and poor proliferation. To develop successful car...

Preparation of bonelike apatite composite for tissue engineering scaffold

A novel sponge composed of a poly (lactic acid) composite skeleton covered with bonelike apatite (b-HA) was produced via a particleleaching technique combined with a biomimetic processing. The sponge has a large porosity of w75% with large-sized pores and shows mechanical ductility. After incubation of human osteoblasts for 7 days, numerous cells attached to the surface of the skeleton, which w...